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Research Objective:
The overall objective of this
Program is to demonstrate that a combination of
low-bandwidth adaptive optics and an optimized
deconvolution technique can be used to increase retinal
multispectral imaging resolution and that the resulting
instrument will improve the level of ophthalmological
healthcare. To meet this objective we propose to complete
the following tasks:
Task 1. To develop
the theory of retinal image formation under the
anisoplanatic conditions including determining the optimal
phase correction/measurements algorithms.
Task 2. To design
and manufacture a specialized Shack-Hartman sensor to fit
a multispectral fundus camera optical system.
Task 3. To
design and manufacture an appropriate reference source for
dynamically maintaining retinal focus. This "focus on
demand" allows the best viewing of the area of
interest on the retina under anisoplanatic conditions.
Task 4. To modify
an existing flexible mirror design to achieve the best
performance in the correction of low-order human eye
aberrations and adapt it to the fundus imager optical
design.
Task 5. To adapt
the deconvolution algorithm for optimal functioning when
coupled to the adaptive optics low-order corrector. To
optimize the related software for PC computers.
Task 6. To perform laboratory
tests of the complete breadboard system against known
degradations using a multispectral fundus imaging system.
To collect quantitative optical performance data using the
as-built hardware.
Task 7. To conduct
limited clinical demonstrations in Russia and the United
States.
All these tasks have been
completed. Two units of the retinal
imager with adaptive compensation of eye aberrations have
been built. Technical details can be found
[
here ]
This
work has been awarded the [
NATO Science Partnership Prize
in 2003 ].
The
developed fundus imager has been patented in US (US 6331059
, December 18, 2001) |
